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T*
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T*
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[(recommendation)-545.4(or)-539.1(prescription)-535.9(of)-539.1(medication)-542.8(for)-541.2(high)-533.2(blood)]TJ
T*
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T*
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(2)Tj
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[(\))-274(o)0(r)-279.8(class)-287(3)-277.7(\()0()52.7(high-risk,)58.7()]TJ
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(2)Tj
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[(\))-185.5(obesity.)]TJ
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(25)Tj
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T*
[(heart)-495.9(surgery)-485.9(\(bypass,)-493.8(angioplasty,)-489.9(or)-488.5(stent)-489.7(placement\).)-496.1(Heavy)]TJ
T*
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(7)Tj
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T*
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[(Walking,)-334.4(none)-11343.8(25.2)-336.6(\(957\))-3132.6(24.9)-330.2(\(231\))-3366.6(23.7)-330.2(\(232\))-2443.4(24.1)-336.6(\(223\))-3923(27.8)-336.6(\(271\))]TJ
0 -1.1128 TD
[(Weight)-331.9(training,)-332.2(none)-8391(34.8)-336.6(\(1323\))-2632.6(32.7)-330.2(\(303\))-3366.6(33.8)-330.2(\(331\))-2443.4(35.8)-336.6(\(331\))-3923(36.8)-336.6(\(358\))]TJ
T*
[(Total,)-333.2(lowest)-334.5(quartile,)]TJ
/F6 1 Tf
9.3073 0 TD
()Tj
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[(5)-334.6(mets/week)-2352.1(25.6)-336.6(\(972\))-3132.6(21.4)-330.2(\(199\))-3366.6(24.0)-330.2(\(235\))-2443.4(25.5)-336.6(\(236\))-3923(31.1)-336.6(\(302\))]TJ
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0 -1.1065 TD
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0 -1.1128 TD
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T*
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0 -1.1065 TD
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0 -1.1128 TD
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T*
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T*
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0 -1.1065 TD
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18.836 0 TD
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[(QOL,)-331.9(quality)-325.6(of)-326.4(life;)-333.1(SD,)-329.4(standard)-327.2(deviation.)]TJ
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()Tj
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ET
59.754 302.173 490.167 .22681 re
f
59.754 87.024 490.167 .22675 re
f
274.394 282.784 275.527 .22675 re
f
59.754 264.983 490.167 .28345 re
f
BT
/F8 1 Tf
8.9663 0 0 8.9663 70.1858 317.8204 Tm
(Table)Tj
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2.9971 0 TD
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[(in)-331.6(Cognition-Related)-339.4(Quality)-329.7(of)-335.1(Life,)-336(Harvard)-335.7(Football)-331.9(Players)-335(Health)-333.9(Study,)]TJ
/F4 1 Tf
37.8363 0 TD
(2015)Tj
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()Tj
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/F8 1 Tf
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(\(N)Tj
/F6 1 Tf
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(\)*)Tj
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[(Age-)-338(and)-333.7(race-adjusted)-3769.7(Further)-334(adjusted)-330.2(for)-338.9(concussion)-335.1(symptoms)]TJ
7.7898 -1.7198 TD
[(Risk)-334.3(Ratio)-334.2(\(95%)-331.6(condence)-340.4(interval\))]TJ
/F4 1 Tf
-31.7284 -2.0929 TD
[(Risk)-336.8(factors)]TJ
0 -1.1128 TD
[(Current)-335.4(smoking)-17715.8(1.50)-336.6(\(1.34,)-329(1.68\)***)-8917.4(1.34)-330.2(\(1.20,)-335.3(1.50\)***)]TJ
0 -1.1065 TD
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0 -1.1128 TD
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T*
[(Sleep)-340.1(apnea)-333.6(history)-16536.5(1.46)-336.6(\(1.37,)-329(1.56\)***)-8917.4(1.23)-330.2(\(1.15,)-335.3(1.30\)***)]TJ
0 -1.1065 TD
[(Sleep)-340.1(duration,)]TJ
/F6 1 Tf
6.4936 0 TD
(<)Tj
/F4 1 Tf
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[(5)-334.6(vs.)]TJ
/F6 1 Tf
2.3015 0 TD
()Tj
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[(5)-170.2(h/night)-11149.6(1.69)-336.6(\(1.58,)-329(1.81\)***)-8917.4(1.25)-330.2(\(1.18,)-335.3(1.33\)***)]TJ
-9.8954 -1.1128 TD
[(Body)-337.9(mass)-335.2(index,)]TJ
/F6 1 Tf
7.6444 0 TD
()Tj
/F4 1 Tf
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[(35)-334.1(vs.)]TJ
/F6 1 Tf
2.801 0 TD
(<)Tj
/F4 1 Tf
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[(25)-169.7(kg/m)]TJ
6.7246 0 0 5.9768 192.3023 196.9511 Tm
(2)Tj
8.9663 0 0 8.9663 279.9495 192.9826 Tm
[(1.33)-336.6(\(1.11,)-329(1.59\)**)-9417.4(1.12)-330.2(\(0.96,)-335.3(1.30\))]TJ
-24.5582 -1.1128 TD
[(Cardiovascular)-338.1(disease)-339(history)-12142.1(1.18)-336.6(\(1.08,)-329(1.29\)***)-8917.4(1.11)-330.2(\(1.02,)-335.3(1.19\)**)]TJ
T*
[(Stroke)-339.8(history)-18825.4(1.38)-336.6(\(1.18,)-329(1.61\)***)-8917.4(1.18)-330.2(\(1.02,)-335.3(1.35\)*)]TJ
0 -1.1065 TD
[(High)-334.2(blood)-336.7(pressure)-337.3(history)-13160.1(1.23)-336.6(\(1.14,)-329(1.32\)***)-8917.4(1.14)-330.2(\(1.07,)-335.3(1.21\)***)]TJ
0 -1.1128 TD
[(Diabetes)-338.3(history)-17933.9(1.22)-336.6(\(1.11,)-329(1.35\)***)-8917.4(1.17)-330.2(\(1.08,)-335.3(1.28\)***)]TJ
T*
[(Physical)-337.5(impairment)-16195.7(2.21)-336.6(\(2.08,)-329(2.34\)***)-8917.4(1.62)-330.2(\(1.53,)-335.3(1.73\)***)]TJ
T*
[(High)-334.2(pain)-333.3(interference)-344.5(in)-331.8(daily)-330.5(life)-10228.9(2.70)-336.6(\(2.52,)-329(2.88\)***)-8917.4(1.96)-330.2(\(1.82,)-335.3(2.10\)***)]TJ
0 -1.1065 TD
[(High)-334.2(depressive)-340.2(symptoms)-13546.9(2.39)-336.6(\(2.26,)-329(2.52\)***)-8917.4(1.72)-330.2(\(1.62,)-335.3(1.82\)***)]TJ
0 -1.1128 TD
[(High)-334.2(anxiety)-338.3(symptoms)-14817.8(2.46)-336.6(\(2.32,)-329(2.60\)***)-8917.4(1.77)-330.2(\(1.67,)-335.3(1.87\)***)]TJ
T*
[(History)-334.2(of)-336.7(football-related)-339.6(concussion)-335.1(symptoms,)]TJ
1.0053 -1.1065 TD
[(highest)-330.7(vs.)-331.9(lowest)-340.8(quartile)]TJ
23.5528 1.1065 TD
[(4.55)-336.6(\(3.94,)-329(5.26\)***)-12831.3()]TJ
7.9702 0 0 7.9702 67.748 75.2314 Tm
[(*Each)-308.8(risk)-314.9(factor)-305.1(was)-313.6(entered)-309.9(as)-313.2(the)-315.6(independen)12.7(t)-309.4(variable)-313.5(in)-314.4(separate)-305.1(models)-306.9(adjusted)-308.1(for)-313.5(age)-313.2(at)-310.5(questionnair)11.3(e)-314.1(and)-317.1(race/eth)10.5(nicity.)-312.4(For)-307.9(variables)-312.6(wit)]TJ
60.006 0 TD
(h)Tj
-61.009 -1.1239 TD
[(more)-393(than)-384.6(one)-395.3(level,)-390.3(including)-378.3(alcohol,)-386.2(body)-390(mass)-392(index,)-381.5(and)-395.3(concussio)11.4(n)-389.1(symptoms,)-388.6(only)-388.5(the)-386.7(most)-386.1(severe)-393(is)-393.9(shown.)-383.5(Physical)-384.1(activity)-389.2(in)-392.7(metabolic)]TJ
0 -1.131 TD
[(equivalent)-325.8(\()-86.7(METS\))-323.9(hours/week)-325.5(was)-327.9(calculated)-325.1(from)-329.2(reported)-329.4(frequency)-324.9(of)-333.6(ve)-329.1(types)-326.8(of)-333.6(exercise,)-325.4(then)-327.7(divided)-327.1(into)-330.1(quartiles.)]TJ
/F1 1 Tf
8.9663 0 0 8.9663 302.3999 34.9228 Tm
(3)Tj
ET
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[(The)-310.6(prevalence)-317.3(of)-311.4(potentially)-310.4(modiable)-314.1(or)-311.5(treatable)-310.8(cognitive)]TJ
-1.1128 -1.1128 TD
[(risk)-322(factors)-321.7(among)-326(the)-321.1(healthy)-319.3(concussed)-327.7(was)-321.6(compared)-325.6(with)-319.2(the)]TJ
T*
[(unhealthy)-242.4(concussed)-245.5(\(men)-240.5(who)-242.1(experienced)-247.3(the)-245.2(highest)-242.2(quartile)-243.2(of)]TJ
0 -1.1065 TD
[(concussion)-398.4(symptoms)-395.3(during)-395.7(their)-396.3(playing)-392.7(career)-404(and)-393(either)-398.2(did)]TJ
0 -1.1128 TD
[(not)-419.9(report)-419.7(or)-418.9(did)-419.9(report)-426(current)-421.6(impairment)-420(in)-420.4(cognition-related)]TJ
T*
[(QOL\).)-414.7(Similarly,)-420.1(we)-415.7(examined)-415.6(the)-416(prevalence)-418.5(of)-418.9(cognitive)-410.8(risk)]TJ
0 -1.1065 TD
[(factors)-555.6(among)-559.9(men)-554.6(in)-553.1(the)-555.1(study)-559.2(who)-551.9(experienced)-557.1(the)]TJ
/F5 1 Tf
24.1598 0 TD
(fewest)Tj
/F4 1 Tf
-24.1598 -1.1128 TD
[(concussion)-575.4(symptoms)-572.3(during)-572.8(their)-573.4(playing)-569.8(career)-581(\(the)-569.8(lowest)]TJ
T*
[(quartile\),)-292.5(separately)-301.2(examining)-290.2(men)-295.3(with)-293.9(and)-291.8(without)-296.5(impairment)]TJ
T*
[(in)-344.5(cognition-related)-342.8(QOL.)-343(In)-343.1(addition)-345.7(we)-339.9(conducted)-342(a)-343.4(sensitivity)]TJ
0 -1.1065 TD
[(analysis)-213.7(restricted)-216.8(to)-211.7(men)-213.1(age)-212(35)-214(years)-214.8(or)-210.3(younger)-210.3(at)-214.1(the)-213.6(time)-214.4(of)-210.3(the)]TJ
0 -1.1128 TD
[(questionnaire,)-437(who)-431.8(may)-434.4(have)-432.8(had)-430.9(more)-436.6(accurate)-432.1(recall)-438.6(of)-431.6(their)]TJ
T*
[(concussion)-303.5(exposure)-308.2(during)-300.9(their)-301.5(playing)-304.2(years)-303.4(than)-308(older)-303.8(men)-301.7(in)]TJ
T*
[(the)-283.2(study.)]TJ
/F1 1 Tf
0 -3.2816 TD
(Results)Tj
/F4 1 Tf
1.1128 -1.8336 TD
[(In)-185(ge)17.5(ne)17.5(ra)14.9(l,)-189.8(co)17.5(gn)13.6(it)18.2(iv)15.9(e)-191.6(r)0(i)13.3(s)0(k)-183.6(f)0(a)14.9(c)0(t)13.5(o)0(r)17.3(s)-190.4(we)14.2(re)-187.4(mo)16.4(re)-187.4(pr)17.3(ev)17.5(al)13.5(ent)-175.7(in)-186.4(me)14(n)-189.2(who)]TJ
-1.1128 -1.2203 TD
[(re)14.9(po)13.6(rt)19.6(ed)-374.5(mor)20.6(e)-381.3(con)24.3(cus)23.2(si)14.7(on)-378.4(sy)18.8(mp)16.4(to)15.9(ms)-376.8(at)-378.5(th)15.9(e)-381.3(t)0(i)18.2(m)0(e)-378(o)0(f)-374.7(f)0(o)17.3(o)0(t)15.9(b)0(a)17.5(l)0(l)-380.1(h)13.1(ead)]TJ
T*
[(in)15.9(ju)15.9(ry)-286.2(\(Ta)21.9(bl)15.9(e)-299.1(1)0(\))17.3(.)-300.1(Th)20.1(er)14.9(e)-299.1(w)0(e)14.2(r)0(e)-288.6(par)21.7(ti)18.2(cul)20.3(ar)14.9(ly)-287.6(la)13.5(rg)17.3(e)-299.1(d)0(i)15.9(f)0(f)14.7(e)0(r)14.9(e)0(n)17.5(c)0(e)15.1(s)-297.9(in)-287.6(pre)21.7(v-)]TJ
27.9978 22.0037 TD
[(al)13.5(enc)21.9(e)-318.1(o)0(f)-311.4(pai)20.3(n)-322(i)0(n)15.9(t)0(e)19.8(r)0(f)14.7(e)0(r)14.9(enc)21.9(e)-318.1(i)0(n)-312.9(dai)20.3(ly)-306.5(lif)22.4(e)-324.4(\()0(1)17.3(1)0(.)16.5(8)-315.7(vs)12.4(.)-319.1(6)0(1)13.6(.)0(1)16.5(%)0(\))15.2(,)-319.1(h)13.1(i)0(g)15.9(h)-322(de)17.5(-)]TJ
0 -1.2203 TD
[(pre)21.7(ssi)20.4(ve)-406.1(sy)18.8(mp)16.4(to)15.9(ms)-408.4(\(5)17.3(.4)-407.1(vs)18.8(.)-413.9(4)0(0)13.6(.)0(9)16.5(%)0(\))15.2(,)-413.9(h)13.1(i)0(g)15.9(h)-416.8(an)17.5(xi)15.9(et)13.5(y)-410.5(s)0(y)12.4(m)0(p)16.4(t)0(o)15.9(m)0(s)-402.1(\(5.)20.7(5)]TJ
0 -1.2266 TD
[(ver)21.7(su)12.4(s)-190.4(4)13.1(4.)16.5(5%\))22(,)-192.6(p)13.1(hy)13.6(si)14.7(ca)15.1(l)-186.9(i)0(m)12.4(p)0(a)17.5(i)0(r)13.3(m)0(e)14(n)13.1(t)-193.2(\()0(1)17.3(0)0(.)16.5(1)-189.2(ve)17.5(rs)16.2(us)-183.6(43)13.6(.8)16.5(%\))15.2(,)-186.3(s)0(h)18.8(ort)-175.9(sl)14.7(ee)15.1(p)]TJ
0 -1.2203 TD
[(du)13.6(ra)14.9(tio)25(n)-182.9(\()0(3)17.3(.)0(9)-166.8(v)0(s)12.4(.)-180(1)13.1(8.3)23.3(%\))15.2(,)-180(a)0(n)17.5(d)-182.9(hi)15.9(st)14.7(o)13.1(r)0(y)-172.3(o)0(f)-172.3(s)0(l)14.7(e)0(e)15.1(p)-176.5(apn)24.3(ea)-174.6(\(1)17.3(5.)16.5(5)-182.9(v)13.1(s.)-174.3(29)19.9(.3%)21.2(\).)]TJ
1.1128 -1.2203 TD
[(Nearly)-795.9(every)-795.4(cognitive)-796.5(risk)-796.2(factor)-795.2(was)-795.8(associated)-799.2(with)]TJ
-1.1128 -1.2266 TD
[(cognition-related)-235.3(QOL)-232.6(in)-230.7(age-)-233.1(and)-228.6(race-adjusted)-235.2(models)-229.5(\(Table)-236(2\).)]TJ
0 -1.2203 TD
[(Associations)-232.9(of)-229.2(physical)-225.1(functioning,)-229.6(pain,)-228.7(depression,)-226.9(and)-228.6(anxiety)]TJ
T*
[(with)-344.5(impairment)-337.8(in)-344.5(cognitive-related)-338.9(QOL)-346.4(were)-337.6(very)-338.2(strong)-340(\(RR)]TJ
0 -1.2266 TD
[(range,)-387.3(2.212.70,)]TJ
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7.4927 0 TD
(p)Tj
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(<)Tj
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[(0.0001)-379.9(for)-376.8(all\).)-380.8(Associations)-384.6(of)-381(short)-378.4(sleep)]TJ
-8.8774 -1.2203 TD
[(duration)-426.5(and)-424.6(low)-423.2(physical)-427.5(activity)-421.7(were)-426.1(also)-423(strong)-428.5(\(RR)-421.6(range,)]TJ
T*
(1.571.69,)Tj
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4.5588 0 TD
(p)Tj
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(<)Tj
/F4 1 Tf
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[(0.0001)-310.3(for)-307.2(all\).)-311.2(In)-311.4(models)-305.4(further)-314.3(adjusted)-307.3(for)-307.2(con-)]TJ
-5.9435 -1.2203 TD
[(cussion)-378.4(symptoms,)-379.2(associations)-377.4(were)-381.8(attenuated)-377.3(but)-375.6(still)-375.2(statisti-)]TJ
0 -1.2266 TD
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